How to save 1.3 million lives

Plus: What does Mexican beer have to do with climate change?

Together with

Mini Museum 1

Welcome back, Shit Givers.

As we barrel towards the end of the year, we're going to take our foot off the pedal a bit to take a breather and also finish up some other big projects.

Your usual Friday newsletter will come a couple more times, but will also be occasionally replaced or complimented with fun end-of-year content β€” our 2nd annual gift guide, annual wrap-up, and more, plus our new limited-series with Rewiring America.

You can read this issue on the website, or you can 🎧 listen to it (Spotify, Apple Podcasts).

πŸ“Ί Miss last week's newsletter? You can watch it on YouTube (in 15 minutes or less).

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COP 27 logo


Around the world in one bullet list

As world climate leaders (and a bazillion fossil fuel lobbyists) continue to slog through negotiations at πŸ‡ͺπŸ‡¬ COP27, here's a round-up of concurrent global climate news:

Fuck around and find out, episode XI:

In climate finance:

Hit the road:

Minerals, metals, and trees:

  • Copper is among the most vital ingredients for a clean future -- here's an incredible dive into the African supply chain

  • Brazil, Indonesia, and the Democratic Republic of Congo will work together once again to protect the world's rainforests

Moral of the story: We've come a very long way, and have equally far to go. The wind's (literally) at our backs. Sun's out, guns solar panels out (you get the point). Meetings like COP are a waste of time if we can't get real commitments out of them.

⚑️What We Can Do: 51 Democratic senators in the US Congress doesn't make up for (barely) losing the House but still goes a hell of a long way towards the US being able to stand by international climate commitments.

You can donate to Senator Warnock's December runoff campaign here, and the invaluable "Georgia Safe and Strong" alliance of local organizers here.


Ghana man studies at computer


Vaccine equity update 11-18

Our World in Data

Like I've been saying

πŸ‘€ Look up: I've been running the Vaccine Equity Update in every newsletter for almost a year. I've talked to global health pros online (here and here) and offline to understand why we haven't vaccinated the world, and what we can do about it.

The receipts are in: A new study out of the UK cross-referenced global excess mortality and vaccine availability info to understand how deaths might have been different had vaccines been equitably distributed, and the theoretical number is absolutely brutal.

The failures are myriad -- logistically and politically complicated (listen to the convos above to get more context), but the morals are not.

I don't have to explain to you that not only were 1.3 million lives sacrificed, but in not vaccinating everyone everywhere, we paved the way for variants like Omicron to tear through countries like the US where shots were plentiful, if often wasted.

We can't go back in time, but we can do better right now, and we can use this info to plan better for the next pandemic.

⚑️What We Can Do: Check out Biobot's wastewater monitoring program for local governments and then take it to your next city council meeting.


Tecate beer 2


Please Don't Go

πŸ’¦ Water runs dry isn't just the 2nd best Boyz II Men song (fight me): it's the future if we don't get our shit together.

Another round-up (I've been off for a minute, you're welcome):

  • Mexican brewers sold $5 billion in beer exports last year, but drought threatens nearly all of it

  • Big Tech, having a rough ride as it is, is finding water needed to cool massive data centers in short supply

  • California's reconsidering desalination plants and how to capture runoff from future megastorms

  • Kenya (see Horn of Africa link above) reversed a ban on drought-resistant genetically modified crops, and some folks aren't pleased

  • The Mississippi River -- used to transport 92% of the country's ag exports -- is drying up even faster, leaving 70% of the Great Plains in drought and now reaching the southeast

  • The new SWOT satellite can measure an incredible 95% of Earth’s water and collect a "complete sample on surface waters" every month (I can't make time to vacuum my air purifiers once a month)

On a planet more or less covered in undrinkable water, we have made ourselves quite the pickle. Decarbonization cannot happen fast enough.

⚑️What We Can Do: Get deeper water news from our friends at Circle of Blue.


Mini Museum 1

The universe is incredible and at Mini Museum, we want to put a piece of that wonder in your hand.

Explore our gift center today to find awesome gifts from the deep history of our planet:

Real dinosaur fossils like the Tyrannosaurus Rex, meteorites from the edges of the solar system, and even pieces of modern history like the Apollo 11 mission!

Explore the collection today and use code BLASTOFF at checkout to save 10%!


Doctor holds phone


Chatbots aren't your friends

CUT TO: Five years ago, when everybody (me) was plugging in video baby monitors and fun smart lights with zero consideration for how secure they were.

There's room for improvement: Those devices have become...somewhat...more secure, but telehealth apps, digital health apps, and health records in general are decidedly not.

  • This will surprise you but mental health data and chatbots do not mix

  • The Opioid Policy Institute and Legal Action Center dropped the results of a 16 month analysis of a dozen substance-use mobile health sites and they're...not private

  • Russian cybercriminals hacked an Australian health insurer, accessing almost 10 million customers, releasing abortion and addiction info into (onto?) the dark web

  • Oh, side note, if you're at the World Cup, DO NOT DOWNLOAD any of the official apps

We can actually fix this: Google just settled with 40 states for almost $400 million for continuing to track your location after you said "no thanks".

And a split Congress means the "Kids Online Safety Act" and "Children and Teens Online Privacy Protection Act" are technically still in play, once the feds figure how to best the best state-level bills.

⚑️What We Can Do: Every bit of leverage matters. Donate to Senator Warnock's December runoff campaign here, and the "Georgia Safe and Strong" alliance of local organizers here, so we can try and get ahead of this dangerous nonsense for once.


Robot playing keyboard

This robot is not an AI and cannot draw a picture

Let's be honest

The news: Took a minute off, and now GPT-4's around the corner and you can ask AI basically any science question, and it'll answer, culled from "48 million papers, textbooks, reference material, compounds, proteins and other sources of scientific knowledge."

This stuff is exciting as hell, but the usual caveats exist:

  • AI isn't real, these are just models, do not trust anything without verification

  • Confidence is a long-tail game and super technical stuff risks losing accuracy in the nitty-gritty

  • AI doesn't have agency

  • AI is not sentient

  • It's an algorithm trained on a data set, not a robot, much less an independent one

  • Any AI's capabilities are incredibly narrow, still

  • Many (not all, but many) of the people and companies building these tools are seeking to raise enormous amounts of money (or already have), they are not neutral parties

  • I cannot emphasize enough again an AI that can make "a picture of two dogs recreating the moon landing but this time the moon is made of vegan ice cream in the style of Dali" cannot also, for example, drive a car or read a mammogram

  • Most of their creators have a relatively little understanding of how the hell they actually work

  • But that doesn't mean they can just get away with hand-wavy bullshit: We bring ENORMOUS biases and blind spots to everything we build, including these tools. Humans set agendas whether we realize it or not.

  • If we're going to acknowledge an AI's limitations, we should acknowledge our own, too (for example, we are 50% banana (and now I have to acknowledge that this statistic, while true, is incomplete, and I was just trying to make a point).

So yeah, be excited. But let's build with ethics, inclusion, and humility up front.

⚑️What We Can Do: Get free weekly updates on ethical AI from our friends at the Montreal AI Ethics Institute.

πŸ—£ Got feedback or thoughts on this issue? Members can comment here. Not a Member yet? You're just $5 away from joining up.


  1. Now we gotta figure out how to make mRNA shots work for everything else

  2. Frontier published a database of carbon removal knowledge gaps

  3. Will we edit the cholesterol gene?

  4. Intel says their deepfake detector is correct 96% of the time

  5. Is meditation as useful as Lexapro?

  6. Why is biopharma investing so unrewarding? Or is it?

  7. This is the first toddler to have been treated for a disease -- before she was born

  8. How to make corn more like cactus

  9. Break up the FDA

  10. The US may get another huge solar panel factory (thanks Ira!)

  11. PLUS: How daily walks help humans AND dogs with dementia, he types through tears

Thanks for reading, and thanks for giving a shit. Have a great weekend.

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